Publications

Process Development and Scale-Up of a Novel Route to 8-Aminooctanoic Acid

The development of robust and scalable synthetic routes remains a crit...

University of Mannheim Highlights InnoSyn’s Breakthroughs in Flow Chemistry Temperature Measurement

Ketoisophorone Synthesis with an Immobilized Alcohol Dehydrogenase

Ketoisophorone Synthesis with an Immobilized Alcohol Dehydrogenase Sol...

Immobilized Glucose Dehydrogenase and an Immobilized Thermostable Cyclohexanone Monooxygenas

Sole, Jordi; Brummund, Jan; Caminal, Gloria; Schurman, Martin; Alvaro,...

Enzymatic Synthesis of Trimethyl-ε-caprolactone: Process Intensification and Demonstration on a 100 L Scale

Enzymatic synthesis of trimethyl-ε-caprolactone: Process intensificati...

Exploring Castellaniella Defragrans Linalool (De)Hydratase-isomerase for Enzymatic Hydration of Alkenes

Engleder, Matthias; Mueller, Monika; Kaluzna, Iwona; Mink, Daniel; Sch...

Evolving the Promiscuity of Elizabethkingia Meningoseptica Oleate Hydratase for the Regio and Stereoselective Hydration of Oleic Acid Derivatives

Evolving the Promiscuity of Elizabethkingia meningoseptica Oleate Hydr...

A Co-expression System to Shift the Equilibrium of Transamination Reactions Toward the Synthesis of Enantiomerically Pure Amines

A co-expression system to shift the equilibrium of transamination reac...

Co-immobilization of P450 BM3 and Glucose Dehydrogenase on Different Supports for Application as a Self-sufficient Oxidative Biocatalyst

Co-immobilization of P450 BM3 and glucose dehydrogenase on different s...

Amine Transaminase from Exophiala Xenobiotica

Amine transaminase from Exophiala xenobiotica – Crystal structure and ...

Enantioselective Synthesis of a 2,3-Benzodiazepine Intermediate of BET Inhibitor BAY 1238097 via Catalytic Asymmetric Hydrogenation

Verzijl, Gerard; Hassfeld Jorma; de Vries Andre; Lefort Laurent Enant...

Photoinduced Decarboxylative Borylation: Scaling Visible Light Photochemistery

New Enabling Chiral Crystallization Technologies – Transformation of Racemates into Pure Enantiomers

In recent years a renaissance in chiral crystallization technologies h...

Counteracting Enantiospecific Behavior of Tailor-Made Additives During Chiral Symmetry Breaking: Growth Inhibition Versus Solid-Solution Formation

Tailor-made additives strongly influence the outcome of a crystallizat...

Expanding the Toolbox of R-Selective Amine Transaminases by Identification and Characterization of New Members

“Expanding the Toolbox! New transaminases for the production of chiral...

Development of a Scalable Synthesis of Boronate β-lactamase Inhibitors

Cost-effective and scalable production of the β-lactamase inhibitor by...

Macrocyclic Baeyer-Villiger Monooxygenase Oxidation of Cyclopentadecanone on 1 L Scale

“In the last couple of years our Biocatalysis team at @InnoSyn was ver...