Our service model is thoughtfully designed to deliver flexibility, transparency, and adaptability, ensuring we meet the diverse needs of our customers.
Our service model is thoughtfully designed to deliver flexibility, transparency, and adaptability, ensuring we meet the diverse needs of our customers.
This case study explores the selective partial reduction of esters to aldehydes, a process known for its challenges due to fast reaction kinetics, high exothermicity, and unstable intermediates. Traditional batch methods demand stringent temperature control and slow dosing of DIBAL-H at cryogenic conditions (-70 to -50 ºC), often resulting in over-reduction to alcohols. Here, we present a pilot-scale solution using continuous flow chemistry, achieving outputs of 0.72–1.2 kg/h. By incorporating 3D metal printing for flow reactors, heat exchangers, and static mixers, we demonstrate a scalable and efficient approach to managing this highly reactive process.
This case study examines aerobic alcohol oxidations using nitroxyl radicals like TEMPO and keto-ABNO, highlighting their efficiency and eco-friendliness. Continuous flow reactors excel in safety and scalability, achieving 96% yield for primary alcohols in under 5 minutes. However, batch reactors prove advantageous for secondary alcohols due to catalyst stability, showcasing the complementary benefits of both approaches.
