InnoSyn biocatalysis delivers sustainable solutions using advanced enzyme screening and optimization for chemical synthesis.
Biocatalysis

Go Green with Biocatalysis: Sustainable Paths to Natural Solutions

Biocatalysis uses enzymes or microbial cells as catalysts for chemical synthesis. Biocatalysts are frequently inherently more selective than conventional chemical approaches (chemo-, regio- and enantioselectivity).

Biocatalysis employs enzymes as they are provided by nature and/or are improved in the laboratory as catalysts for challenging chemical reactions. Biocatalysis operates on the interface of biology and chemistry, making the integration of both disciplines in one team indispensable, like we do at InnoSyn.

Typically, biocatalysis is not just replacing a chemical step in a process by an enzymatic one, but enables shortcuts from alternative starting materials or process intermediates. This way shorter and more cost-efficient synthesis routes and chemical processes are possible.

Fast identification of suitable enzymes for novel products or new routes to existing products through we achieve by efficient in silico and wet-lab SCREENING of thousands of enzymes we have available “off the shelf” for all synthetically useful enzyme classes. This is followed by systematic, explorative experimentation to identify, improve and OPTIMIZE the biocatalytic reactions and the enzymes towards high efficiency and productivity. Lastly, we take care of a fast and independent enzyme PRODUCTION for a scalable fermentation and chemical process.

InnoSyn biocatalysis delivers sustainable solutions using advanced enzyme screening and optimization for chemical synthesis.
InnoSyn biocatalysis delivers sustainable solutions using advanced enzyme screening and optimization for chemical synthesis.

Biocatalysis Services

  • Enzyme Discovery, Design (Engineering) and Development
  • Biocatalyst Screening for rapid identification of the best enzymes for the customer application
  • Enzyme Production by Fermentation in microbial hosts (bacteria, yeasts, fungi)
  • Fast Immobilisation tests on selected, scalable carriers
  • Process Development of the biocatalytic process and integration into the overall chemical process
  • Tech Transfer to customer or toller with full support through all phases of process implementation
  • InnoSyn biocatalysis delivers sustainable solutions using advanced enzyme screening and optimization for chemical synthesis.

    Enzymes and Biocatalytic reaction types

    Oxidoreductases
    • Oxidations
    • Hydroxylations
    • Reductive Aminations
    Transferases
    • Transaminations
    • Phosphorylations
    • Glycosylations
    Hydrolases
    • Ester synthesis and hydrolysis
    • Amide synthesis and hydrolysis
    • Nitrile hydrolysis
    • Dehalogenations
    • Deaminations
    Lyases
    • Carbon-carbon bond formation (aldolases & HNLs)
    • Decarboxylations (amino and keto acid decarboxylases)
    • Ammonia additions
    • Water additions (esp. oleate and fatty acid hydratases)
    Isomerases
    • Racemisations
    • Epimerisations
    Ligases
    • Esp. ATP-recycling for ligation reactions

    Alcohol Dehydrogenase (ADH)

    Baeyer Villiger Monooxygenases (BMVO)

    Cytohrome P450

    Hydratases (HYDS)

    Nitralases (NIT)

    Transaminases (TA)

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