Our Hydratase Technology is the next generation of idea development available in our expanding portfolio. Partner with us in our successful track record of development and implementation of new and improved processes to chemicals for all market segments. Watch the video: Your browser does not...
Visiblelight - induced decarboxylative borylation was successfully implemented and scaled-up as key step in a novel route towards vaborbactam. The transformation was carried out in a falling-film photoreactor on a 10 g-scale. Under mild conditions (420 nm KEYWORDS: Photochemistry, Borylation, Decarboxylation, Visible light, scale-up, Peer reviewed. blue...
Marijn Rijkers, Program Director Biobased shared and discussed his vision towards transition to circular chemicals and materials; What it takes to make it happen. Read the full article...
Dutch television program “Nederland Maakt Het” recorded InnoSyn in action. Have a look!...
Quirinus Rinus B. Broxterman, Michele C.C. Janssen, Marinus Marijn P.W.M. Rijkers. Chimica Oggi - Chemistry Today - vol. 35(4) July/August 2017...
Sodium azide is the reagent of choice to prepare sterically hindered amines, triazoles and tetrazoles, functional moieties often encountered in new APIs (Active Pharmaceutical Ingredients). However, the use of azides in batch-wise productions is severely hampered by safety risks. Sodium azide is highly toxic, can...
Verzijl, Gerard; Hassfeld Jorma; de Vries Andre; Lefort Laurent Enantioselective Synthesis of a 2,3-Benzodiazepine Intermediate of BET Inhibitor BAY 1238097 via Catalytic Asymmetric Hydrogenation. Org. Process Res. Dev. (2020), 24, 2, 255–260. DOI/10.1021/acs.oprd.9b00519...
Telzerow, Aline; Hobisch, Markus; Müller, Monika; Schürmann, Martin; Schwab, Helmut; Steiner, Kerstin A co-expression system to shift the equilibrium of transamination reactions toward the synthesis of enantiomerically pure amines. Molecular Catalysis (2019), 471, 38-43. DOI:10.1016/j.mcat.2019.04.006...
Telzerow, Aline; Paris, Juraj; Hakansson, Maria; Gonzalez-Sabin, Javier; Rios-Lombardia, Nicolas; Schuermann, Martin; Groeger, Harald; Moris, Francisco; Kourist, Robert; Schwab, Helmut; et al. Amine transaminase from Exophiala xenobiotica - Crystal structure and engineering of a fold IV transaminase that naturally converts biaryl ketones. ACS Catalysis (2019), 9 (2),...