If you are looking for a scalable route of a new chemical entity, or for a new chemical route to your existing product, InnoSyn has the experience to help in identifying the most suitable solution . Typically, we address this by a route scouting exercise, all tailored to the request and in close collaboration with the customer:
Assign an owner
Collect all known routes (patent and open literature) and new ideas by a multi-competence brainstorm
Evaluation of routes (potential cost estimate, amount of inventions to do, freedom to operate, customer’s and Innosyn’s experience)
Fine tuning and prioritization
Experimental feasibility – most critical step(s) first
Full experimental proof of principle
Scale up
Key to success, is to have an unbiased and open view which synthetic technology is the most suitable. Sometimes this can be a process where a biocatalytic step makes all the difference, while in other cases the safe use of a hazardous intermediate in a flow reactor (flow chemistry) shortcuts the process drastically, or yet in another case a chiral chemocatalyst delivers that specific chiral building block in the most economical way.
A typical example is given below where initially about 6 different routes were shortlisted for a new route to the chiral building block shown in the center. After evaluation we opted successfully for a 2-step route using an phenyl ammonia lyase adding ammonia selectively to the cinnamate, followed by copper catalysed C-N bond formation (all in water).
References: ChemCatChem 2011, 3, 289 – 292, DOI: 10.1002/cctc.201000435
Biocatalysis can be defined as the use of enzymes or other biological catalysts for industrial synthetic chemistry. Enzymatic catalysis is often inherently more selective than conventional chemical approaches.
Chemocatalysis offers unique solutions for the synthesis of complex molecules in terms of cost, short-cuts, and waste reduction. Depending on your target compound, our experts will select the best option between homogeneous, heterogeneous or organocatalysis.
Flow Chemistry or continuous manufacturing of chemicals enables the safe application of extreme reaction conditions and/or hazardous reagents, as such being one of the key synthetic technologies for ultimate route scouting.
Crystallization is one of the strongest techniques for the chemical purification of organic compounds. In nearly all industrial processes crystallization is used as a method to produce, purify or recover solid compounds.
Photochemistry employs photons as reagent – which leave no residue – and it induces chemical transformations otherwise difficult to achieve under mild conditions.
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