Crystallization

Crystallization

In nearly all industrial processes crystallization is used as a method to produce, purify or recover solid compounds. In addition crystallization is frequently used to improve the enantiomeric excess of partially enriched chiral compounds obtained by i.e. (catalytic) asymmetric synthesis or biocatalytic processes. Crystallization can also be used to separate the enantiomers of a racemate by diastereomeric salt formation or preferential crystallization (Pasteurian resolution).

Polymorphism and crystal habit frequently has a huge influence on the solid properties, such as filterability, solubility, dissolution rate and physical behavior. In depth knowledge of crystallization techniques and polymorphism can help in crystal habit modifications and as such making the specific handlings in process step economically viable.

At Innosyn, we have a long track record in screening and optimization of crystallization processes up to production scale. Controlled crystallization is key. We can help you with identification and optimization of a crystallization process at different stages, e.g. combining chemical synthesis with a crystallization isolation procedure, or, improving a multiple crystallization process to a single controlled crystallization purification, or a polymorph procedure, and many other options.

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Next to the general experience in optimizing crystallization processes for production scale, Innosyn has (co-)developed a long list of ‘classical resolutions’ by smart crystallizations: diastereomeric salt formation, preferential crystallization, crystallization induced asymmetric transformation, and Viedma ripening (converting a racemic solid compound in a single enantiomer – see schematic drawing).

Schematic representation of the experimental procedure of the attrition enhanced deracemization of racemic mixtures (conglomerates):