In the last couple of years our Biocatalysis team at @InnoSyn was very active in the development and scale up of numerous biocatalytic oxidation processes. As one reaction example here is a detailed process description of the Baeyer-Villiger...
“Expanding the Toolbox! New transaminases for the production of chiral and functional amines. The latest publication co-authored by us and our long-lasting collaboration Partners at ACIB and TU Graz....
Cost-effective and scalable production of the β-lactamase inhibitor by utilization two key steps: nickel-catalyzed boron insertion followed by enantioselective cyclopropanation resulting in the final cyclic product formation. Check it out!...
This article on producing #vanillin in clean enzymatic reactions by oxidation of vanillyl alcohol with pure oxygen results from a very fruitful collaboration of us (#InnoSyn) with the researchers of the Autonomous University of Barcelona (UAB) in the framework of the EU project #ROBOX on...
In recent years a renaissance in chiral crystallization technologies has enabled the complete deracemization of chiral compounds....
Visiblelight - induced decarboxylative borylation was successfully implemented and scaled-up as key step in a novel route towards vaborbactam. The transformation was carried out in a falling-film photoreactor on a 10 g-scale. Under mild conditions (420 nm KEYWORDS: Photochemistry, Borylation, Decarboxylation, Visible light, scale-up, Peer reviewed. blue...
Quirinus Rinus B. Broxterman, Michele C.C. Janssen, Marinus Marijn P.W.M. Rijkers. Chimica Oggi - Chemistry Today - vol. 35(4) July/August 2017...
Verzijl, Gerard; Hassfeld Jorma; de Vries Andre; Lefort Laurent Enantioselective Synthesis of a 2,3-Benzodiazepine Intermediate of BET Inhibitor BAY 1238097 via Catalytic Asymmetric Hydrogenation. Org. Process Res. Dev. (2020), 24, 2, 255–260. DOI/10.1021/acs.oprd.9b00519...
Telzerow, Aline; Hobisch, Markus; Müller, Monika; Schürmann, Martin; Schwab, Helmut; Steiner, Kerstin A co-expression system to shift the equilibrium of transamination reactions toward the synthesis of enantiomerically pure amines. Molecular Catalysis (2019), 471, 38-43. DOI:10.1016/j.mcat.2019.04.006...
Telzerow, Aline; Paris, Juraj; Hakansson, Maria; Gonzalez-Sabin, Javier; Rios-Lombardia, Nicolas; Schuermann, Martin; Groeger, Harald; Moris, Francisco; Kourist, Robert; Schwab, Helmut; et al. Amine transaminase from Exophiala xenobiotica - Crystal structure and engineering of a fold IV transaminase that naturally converts biaryl ketones. ACS Catalysis (2019), 9 (2),...