Sodium azide is the reagent of choice to prepare sterically hindered amines, triazoles and tetrazoles, functional moieties often encountered in new APIs (Active Pharmaceutical Ingredients). However, the use of azides in batch-wise productions is severely hampered by safety risks. Sodium azide is highly toxic, can...
Obtaining enantiopure compounds from a racemic mixture without any additional chiral reagent. Not a dream, but a new reality. By using racemizing conditions and specific crystallization behavior the solid phase of a racemic mixture can be fully converted into the enantiomerically pure form of the...
Tandem Catalysis Metathesis Hydrogenation Natural Fatty acid esters can be converted into long chain (saturated or unstaturared) biobased diols via an orthogonal tandem catalysis process: i.e. self-metathesis of the unsaturated acid ester, followed by a catalytic ester hydrogenation protocol. An unique feature developed by Innosyn is based...