The levulinic acid product tree: a versatile opportunity in the bio-based economy
Quirinus Rinus B. Broxterman, Michele C.C. Janssen, Marinus Marijn P.W.M. Rijkers. Chimica Oggi - Chemistry Today - vol. 35(4) July/August 2017...
17 June, 2020
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Case – Azide Chemistry Made Safe
Sodium azide is the reagent of choice to prepare sterically hindered amines, triazoles and tetrazoles, functional moieties often encountered in new APIs (Active Pharmaceutical Ingredients). However, the use of azides in batch-wise productions is severely hampered by safety risks. Sodium azide is highly toxic, can...
16 June, 2020
Enantioselective Synthesis of a 2,3-Benzodiazepine Intermediate of BET Inhibitor BAY 1238097 via Catalytic Asymmetric Hydrogenation
Verzijl, Gerard; Hassfeld Jorma; de Vries Andre; Lefort Laurent Enantioselective Synthesis of a 2,3-Benzodiazepine Intermediate of BET Inhibitor BAY 1238097 via Catalytic Asymmetric Hydrogenation. Org. Process Res. Dev. (2020), 24, 2, 255–260. DOI/10.1021/acs.oprd.9b00519...
16 June, 2020
A co-expression system to shift the equilibrium of transamination reactions toward the synthesis of enantiomerically pure amines
Telzerow, Aline; Hobisch, Markus; Müller, Monika; Schürmann, Martin; Schwab, Helmut; Steiner, Kerstin A co-expression system to shift the equilibrium of transamination reactions toward the synthesis of enantiomerically pure amines. Molecular Catalysis (2019), 471, 38-43. DOI:10.1016/j.mcat.2019.04.006...
16 June, 2020
Amine transaminase from Exophiala xenobiotica
Telzerow, Aline; Paris, Juraj; Hakansson, Maria; Gonzalez-Sabin, Javier; Rios-Lombardia, Nicolas; Schuermann, Martin; Groeger, Harald; Moris, Francisco; Kourist, Robert; Schwab, Helmut; et al. Amine transaminase from Exophiala xenobiotica - Crystal structure and engineering of a fold IV transaminase that naturally converts biaryl ketones. ACS Catalysis (2019), 9 (2),...
16 June, 2020
Co-immobilization of P450 BM3 and glucose dehydrogenase on different supports for application as a self-sufficient oxidative biocatalyst
Sole, Jordi; Caminal, Gloria; Schuermann, Martin; Alvaro, Gregorio; Guillen, Marina Co-immobilization of P450 BM3 and glucose dehydrogenase on different supports for application as a self-sufficient oxidative biocatalyst. Journal of Chemical Technology and Biotechnology (2019), 94 (1), 244-255. DOI:10.1002/jctb.5770...
16 June, 2020
Enzymatic synthesis of trimethyl-ε-caprolactone: Process intensification and demonstration on a 100 L scale.
Sole, Jordi; Brummund, Jan; Caminal, Gloria; Alvaro, Gregorio; Schurmann, Martin; Guillen, Marina Enzymatic synthesis of trimethyl-ε-caprolactone: Process intensification and demonstration on a 100 L scale. Organic Process Research & Development (2019), 23 (11), 2336-2344. DOI:10.1021/acs.oprd.9b00185...
16 June, 2020
Evolving the Promiscuity of Elizabethkingia meningoseptica Oleate Hydratase for the Regio- and Stereoselective Hydration of Oleic Acid Derivatives
Engleder, Matthias; Strohmeier, Gernot A.; Weber, Hansjoerg; Steinkellner, Georg; Leitner, Erich; Mueller, Monika; Mink, Daniel; Schuermann, Martin; Gruber, Karl; Pichler, Harald Evolving the Promiscuity of Elizabethkingia meningoseptica Oleate Hydratase for the Regio- and Stereoselective Hydration of Oleic Acid Derivatives. Angewandte Chemie, International Edition (2019), 58 (22), 7480-7484....
16 June, 2020
Exploring Castellaniella defragrans linalool (de)hydratase-isomerase for enzymatic hydration of alkenes
Engleder, Matthias; Mueller, Monika; Kaluzna, Iwona; Mink, Daniel; Schuermann, Martin; Leitner, Erich; Pichler, Harald; Emmerstorfer-Augustin, Anita Exploring Castellaniella defragrans linalool (de)hydratase-isomerase for enzymatic hydration of alkenes. Molecules (2019), 24 (11), 2092. DOI:10.3390/molecules24112092...
16 June, 2020
Ketoisophorone Synthesis with an Immobilized Alcohol Dehydrogenase
Sole, Jordi; Brummund, Jan; Caminal, Gloria; Schuerman, Martin; Alvaro, Gregorio; Guillen, Marina Ketoisophorone Synthesis with an Immobilized Alcohol Dehydrogenase. ChemCatChem (2019), 11 (19), 4862-4870. DOI:10.1002/cctc.201901090...
16 June, 2020